ea0073oc2.6 | Oral Communications 2: Diabetes, Obesity, Metabolism and Nutritionw | ECE2021
Genchi Valentina Annamaria
, Cignarelli Angelo
, Perrini Sebastio
, Caccioppoli Cristina
, DSebastio Sebastio
, Natalicchio Sebastio
, Laviola Luigi
, Giorgino Francesco
Insulin is a major endocrine hormone able to regulate whole-body energy disposal and lipid metabolism. Particularly, insulin stimulates the renewal of the adipose tissue (AT) via activation of insulin receptors (IR) consisting of two splicing variants: a short isoform (IRa) involved in cell proliferation, and a long isoform (IRb) mainly implicated in metabolic responses. The contribution of these isoforms to the AT expansion is still poorly understood. We investigated the expr...